Je vais te remercier car grâce à toi, j'ai replongé la tête dans mes notes et ça faisait longtemps, peut être trop!
Alors je "comprends" ton engouement pour ce produit car tu dis avoir fait des analyses et que donc ce produit ou protocole est presque passé inaperçu. Pourtant je vais émettre un grand bémol à ton ressentit. En effet, le clomid a les certaines propriétés que tu vantes. Cependant il a aussi de sacrés effets secondaires :
*dépression;
*des « éclairs » dans les yeux
*sensibilité à la lumière
*symptômes de troubles hépatiques (par ex. le jaunissement du blanc des yeux ou de la peau, une douleur abdominale, un appétit médiocre, une urine foncée ou des selles claires)
*vision double ou diminuée, ou un autre problème de la vue
*vision floue entres autres
Certains de ses effets secondaires peuvent être permanents!
De plus le Clomid était le principal traitement utilisé lors de l'infertilité féminine (ou masculine ) et il permet effectivement d'augmenter la production endogène d'hormone , la spermatogenèse et l'ovogenèse. Bien qu'il ait été affirmé que Clomid "stimule" la production de l'hormone lutéinisante (LH) et donc de la testostérone, en fait l'activité de Clomid n'est pas réalisé par la stimulation de l'hypothalamus et de l'hypophyse, mais en bloquant leur inhibition par les oestrogènes...
Je te mets le résultats d'une étude effectuée dans les années 70 et là le résultat est sans appel :
Pituitary Sensitivity to GnRH
Studies conducted in the late 1970's at the University of Ghent in Belgium make clear the advantages of using Nolvadex instead of Clomid for increasing testosterone levels (1). Here, researchers looked the effects of Nolvadex and Clomid on the endocrine profiles of normal men, as well as those suffering from low sperm counts (oligospermia). For our purposes, the results of these drugs on hormonally normal men are obviously the most relevant. What was found, just in the early parts of the study, was quite enlightening. Nolvadex, used for 10 days at a dosage of 20mg daily, increased serum testosterone levels to 142% of baseline, which was on par with the effect of 150mg of Clomid daily for the same duration (the testosterone increase was slightly, but not significantly, better for Clomid). We must remember though that this is the effect of three 50mg tablets of Clomid. With the price of both a 50mg Clomid and 20mg Nolvadex typically very similar, we are already seeing a cost vs. results discrepancy forming that strongly favors the Nolvadex side.
But something more interesting is happening. Researchers were also conducting GnRH stimulation tests before and after various points of treatment with Nolvadex and Clomid, and the two drugs had markedly different results. These tests involved infusing patients with 100mcg of GnRH and measuring the output of pituitary lh - leutenizing hormone - in response. The focus of this test is to see how sensitive the pituitary is to Gonadotropin Releasing Hormone. The more sensitive the pituitary, the more lh - leutenizing hormone - will be released. The tests showed that after ten days of treatment with Nolvadex, pituitary sensitivity to GnRH increased slightly compared to pre-treated values. This is contrast to 10 days of treatment with 150mg Clomid, which was shown to consistently DECREASE pituitary sensitivity to GnRH (more lh - leutenizing hormone - was released before treatment). As the study with Nolvadex progresses to 6 weeks, pituitary sensitivity to GnRH was significantly higher than pre-treated or 10-day levels. At this point the same 20mg dosage was also raising testosterone and lh - leutenizing hormone - levels to an average of 183% and 172% of base values, respectively, which again is measurably higher than what was noted 10 days into therapy. Within 10 days of treatment Clomid is already exerting an effect that is causing the pituitary to become slightly desensitized to GnRH, while prolonged use of Nolvadex serves only to increase pituitary sensitivity to this hormone. That is not to say Clomid won't increase testosterone if taken for the same 6 week time period. Quite the opposite is true. But we are, however, noticing an advantage in Nolvadex.
Conclusion
To summarize the above research succinctly, Nolvadex is the more purely anti-estrogenic of the two drugs, at least where the hpta - hypothalamic-pituitary-testicular axis - (Hypothalamic-Pituitary-Testicular Axis) is concerned. This fact enables Nolvadex to offer the male bodybuilder certain advantages over Clomid. This is especially true at times when we are looking to restore a balanced hpta - hypothalamic-pituitary-testicular axis - , and would not want to desensitize the pituitary to GnRH. This could perhaps slow recovery to some extent, as the pituitary would require higher amounts of hypothalamic GnRH in the presence of Clomid in order to get the same level of lh - leutenizing hormone - stimulation.
Nolvadex also seems preferred from long-term use, for those who find anti-estrogens effective enough at raising testosterone levels to warrant using as anabolics. Here Nolvadex would seem to provide a better and more stable increase in testosterone levels, and likely will offer a similar or greater effect than Clomid for considerably less money. The potential rise in sex hormone binding globulin levels with Clomid, supported by other research (3), is also cause for concern, as this might work to allow for comparably less free active testosterone compared to Nolvadex as well. Ultimately both drugs are effective anti-estrogens for the prevention of gynecomastia and elevation of endogenous testosterone.
Donc comme dirait mes éminents modèles que sont Anthony Roberts et Dr Scally, en théorie, ça peut marcher mais ça ne fonctionnera pas.
En bref, pendant un cycle un AI est recommandé, l'ajout de hcg est recommandé mais pas obligatoire et en PCT les SERM trouvent leur place et notamment le....Nolvadex!
NB : Je ne dis pas que le clomid est bon à jeter à la poubelle, au contraire, il a sa place en PCT mais le nolva ou les 2 seront plus bénéfiques!
